Ethanol adducts of 6-sulfonyl-substituted 3-hydroxy-chromans and their use as inhalants in diseases
AssigneeHoechst Aktiengesellschaft
InventorsHeinrich Englert, Dieter Mania, Paul-Gerhard Kibat, Doris Gehring, Erich Paulus
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Abstract
The invention relates to ethanol adducts of the compounds of the formula I ##STR1## to a process for their preparation and to their use as inhalants in diseases, in particular in asthma.
Claims6
A crystalline ethanol adduct of the formula I ##STR4## in which R(1) is phenyl which can be substituted by 1 or 2 methyl groups, a chlorine group or both methyl and chlorine groups,
- R(2) and R(3) are identical or different and are hydrogen, methyl or ethyl,
- n is the number 3 or 4,
- and m is 1 or 2.
A method of treating asthma comprising administering an ethanol adduct of the formula I ##STR5## in which R(1) is phenyl which can be substituted by 1 or 2 methyl groups, a chlorine group or both methyl and chlorine groups,
- R(2) and R(3) are identical or different and are hydrogen, methyl or ethyl,
- n is the number 3 or 4,
- and m is 1 or 2;
- as an inhalant to a patient for the treatment of asthma.
A medicament comprising an effective amount of an ethanolate of the formula I ##STR6## in which R(1) is phenyl which can be substituted by 1 or 2 methyl groups, a chlorine group or both methyl and chlorine groups,
- R(2) and R(3) are identical or different and are hydrogen, methyl or ethyl,
- n is the number 3 or 4,
- and m is 1 or 2;
- and at least one pharmaceutically customary additive.
Dependencies are inferred from the claim text.