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US 5,310,749 AGranted
Antiprotozoal composition containing a 2-nitroimidazole derivative and method thereof
AssigneePola Chemical Industries Inc.
InventorsYoshiyuki Miyata, Masakazu Sakaguchi, Toshimitsu Suzuki, Tsutomu Takeuchi, Seiki Kobayashi
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Abstract
Disclosed herein is an antiprotozoal composition containing a 2-nitroimidazole derivative as its active component. This drug is especially useful against Trypanosoma cruzi. Process for the preparation is also disclosed.
Claims2
An antiprotozoal composition which is effective against the protozoan Trypanosoma cruzi containing a 2-nitroimidazole derivative of Formula (I):
- ##STR8## wherein R is --CH.sub.2 OCH.sub.2 CH.dbd.CHCH.sub.2 OH or --CH.sub.2 OCH(CH.sub.2 OH).sub.2, and an acrylic acid-diisobutylvinyl ether copolymer.
A method of treatment of an infectious disease caused by the protozoan Trypanosoma cruzi, which comprises:
- administering to a patient a therapeutically effective amount of an antiprotozoal containing as its active component a 2-nitroimidazole derivative of Formula (I):
- ##STR9## wherein R is --CH.sub.2 OCH.sub.2 CH.dbd.CHCH.sub.2 OH or --CH.sub.2 OCH(CH.sub.2 OH).sub.2, and an acrylic acid-diisobutylvinyl ether copolymer.
Dependencies are inferred from the claim text.