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US 5,310,745 AGranted
Antiviral compounds
AssigneeG. D. Searle & Co.
InventorsRichard A. Partis, Francis J. Koszyk, Richard A. Mueller
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AssigneeG. D. Searle & Co.
InventorsRichard A. Partis, Francis J. Koszyk, Richard A. Mueller
Estimating the term…
A method of inhibiting lentivirus is disclosed which comprises mammalian host susceptible to said lentivirus with a virally inhibitory effective amount of an O-acylated derivative of 1,5-dideoxy-1,5-imino-D-glucitol and their N-alkyl, N-acyl and N-aroyl derivatives in which from one to four of the free hydroxyl groups are O-acylated with carboxylic alkanoyl radicals selected from the group consisting of .omega.,.omega.,.omega.-trifluoroalkanoyl having from three to eight carbon atoms, carboxylic cycloalkanoyl groups having from four to eight carbon atoms and carboxylic acyclic alkanoyl groups having from two to ten carbon atoms, wherein the N-aroyl groups contain from 7 to 14 carbon atoms, the N-acyl groups contain from 4 to 8 carbon atoms and the N-alkyl groups contain from 1 to 14 carbon atoms.
The method of inhibiting lentivirus by orally administering to a mammalian host susceptible to said lentivirus a virally inhibitory effective amount of an O-acylated derivative of 1,5-dideoxy-1,5-imino-D-glucitol containing an N-aroyl radical selected from the group consisting of phenylacetyl, benzyloxycarbonyl, biphenylacetyl, phenoxyacetyl, chlorophenylacetyl, cinnamoyl, hydrocinnamoyl and nicotinoyl, and in which from one to four of the free hydroxy groups are acylated with carboxylic alkanoyl groups having from one to eight carbon atoms, provided that when N-aroyl is benzyloxycarbonyl, the carboxylic alkanoyl groups contain from four to eight carbon atoms.
The method of inhibiting lentivirus by orally administering to a mammalian host susceptible to said lentivirus a virally inhibitory effective amount of an O-acylated derivative of 1,5-dideoxy-1,5-imino-D-glucitol containing an N-acyl radical selected from the group consisting of methyl malonyl and ethyl malonyl, and in which from one to four of the free hydroxyl groups are acylated with carboxylic alkanoyl groups having from one to eight carbon atoms.
The method of inhibiting lentivirus by orally administering to a mammalian host susceptible to said lentivirus a virally inhibitory effective amount of 1,5-(butylimino)-1,5dideoxy-D-glucitol, tetrabutyrate.
The method of inhibiting lentivirus by orally administering to a mammalian host susceptible to said lentivirus a virally inhibitory effective amount of 1,5-(butylimino)-1,5dideoxy-D-glucitol, tetraisobutyrate.
Dependencies are inferred from the claim text.