TAN-1251 compounds and their production from penicillium thomii
AssigneeTakeda Chemical Industries, Ltd.
InventorsHideo Shirafuji, Shigetoshi Tsubotani, Takenori Ishimaru, Setsuo Harada
Life of this patent
Estimating the term…
Abstract
A compound of the formula ##STR1## wherein R.sup.1 is hydrogen or a hydrocarbon residue which may be substituted; R.sup.2 is oxo or hydrogen plus hydroxy which may be acylated; R.sup.3 is hydrogen or hydroxy which may be acylated; at least one of the dotted lines represents a single bond, or a salt thereof, produced from Penicillum thomii has potent RA-89 muscarinic receptor blocking activity and is of value as therapeutic agent for parkinsonism, ulcer, etc. or as mydriatics.
Claims12
A compound of the formula ##STR30## wherein R.sup.1 is hydrogen or a substituted or unsubstituted alkyl, alkenyl, or alkynyl group;
- R.sup.2 is oxo or hydrogen and hydroxy, which may be acylated;
- R.sup.3 is hydrogen or hydroxy which may be acylated;
- at least one of the dotted lines represents a single bond, or a salt thereof.
A method of producing a compound of the formula ##STR31## wherein R.sup.3' is hydrogen or a hydroxy;
- at least one of the dotted lines represents single bond;
- provided that where R.sup.3' is hydroxy, the dotted line on the right-hand side represents a single bond and the one of the left hand side represents a double bond, or a salt thereof, comprising culturing [a strain of microorganism belonging to the genus Penicillium thomii RA-89 or a mutant thereof capable of producing at least one compound having the above formula in a culture medium and recovering the compound from the resulting culture broth.
An antispasmodic and antiulcer composition comprising a therapeutically effective amount of a compound of the formula ##STR32## wherein R.sup.1 is hydrogen of a substituted or alkyl, alkenyl, or alkynyl hydrogen group R.sup.2 is oxo or hydrogen and hydroxy which may be acylated;
- R.sup.3 is hydrogen or hydroxy which may be acylated;
- at least one of the dotted lines represents a single bond, or a pharmacologically acceptable salt thereof, and in combination with pharmacologically acceptable carriers.
Dependencies are inferred from the claim text.