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US 5,310,729 AGranted
Interferon-related polypeptides as CR2 ligands and their use for modulating immune cell functions
AssigneeCalifornia Institute of Biological Research
InventorWaldemar Lernhardt
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Abstract
Synthetic polypeptides corresponding to the B lymphocyte CR2 receptor binding site present on an interferon alpha-related CR2 ligand are disclosed together with polypeptide aggregates, compositions, anti-polypeptide antibodies and methods of preparing and using the polypeptides and antibodies.
Claims2
A CR2 ligand consisting of a polypeptide selected from the group consisting of:
- ______________________________________ QLNDLEA, QLNDLEAC, QLNDLEACV, QLNDLEACVI, QLNDLEACVIQ, QQLNDLEA, YQQLNDLEA, LYQQLNDLEA, QLNNLEA, QLNNLEAC, QLNNLEACV, QLNNLEACVI, QLNNLEACVIQ, QQLNNLEA, YQQLNNLEA, and LYQQLNNLEA, ______________________________________
- said ligand being capable of specifically binding to CR2.
CR2 ligand consisting of a polypeptide selected from the group consisting of:
- QNNDVEATS,
- QLNDVEATS,
- QLNNVEATS,
- QLNNLEATS,
- QSNGVEALT,
- QNSGLEALT,
- QNSGLEALI,
- QSNGVEALI,
- NSVGEALI,
- QNAIVEALI, and
- QNAIVEALT,
- ligand being capable of specifically binding to CR2.
9 more elements
Dependencies are inferred from the claim text.