Airborne protectants against oxidative tissue damage
AssigneeVyrex Corporation
InventorsRobert A. Sanchez, Sheldon S. Hendler
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for preventing free radical-induced oxidative damage and inflammatory response in biological tissue. The methods comprise exposing biological tissue to vapor-phase, phenolic antioxidants such as vaporized 2,6-diisopropylphenol.
Claims7
A method for preventing oxidative damage to respiratory tissue, said method comprising exposing the tissue to a phenolic antioxidant compound in vapor form, said compound having the formula:
- ##STR3## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of lower (C.sub.2 -C.sub.4) alkyls, with the proviso that the total number of carbon atoms in R.sup.1 and R.sup.2 sum to at least 4;
- R.sup.3, R.sup.4, and R.sup.5 are members independently selected from the group consisting of H, lower (C.sub.1 -C.sub.6) alkyls, lower (C.sub.1 -C.sub.4) alkoxys, and lower alkyls in which one or more of the atoms is replaced by a heteroatom selected from the group consisting of O, N, and S, with the proviso that the total number of carbons and heteroatoms in groups R.sup.3, R.sup.4 and R.sup.5 does not exceed 5;
- and
- wherein the antioxidant compound is a volatile substance incorporated into a tobacco smoking product.
A method for preventing oxidative damage to biological tissue, the method comprising placing a tissue in a chamber filled with a phenolic antioxidant compound in vapor form, and exposing the tissue to the compound, said compound having the formula:
- ##STR4## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of lower (C.sub.1 -C.sub.4) alkyls, with the proviso that the total number of carbon atoms in R.sup.1 and R.sup.2 sum to at least 4;
- and
- R.sup.3, R.sup.4, and R.sup.5 are members independently selected from the group consisting of H, lower (C.sub.1 -C.sub.6) alkyls, lower (C.sub.1 -C.sub.4) alkoxys, and lower alkyls in which one or more of the atoms is replaced by a heteroatom selected from the group consisting of O, N, and S, with the proviso that the total number of carbons and heteroatoms in groups R.sup.3, R.sup.4 and R.sup.5 does not exceed 5.
A method for preventing oxidative damage to biological tissue, said method comprising exposing the tissue to a phenolic antioxidant compound in vapor form, said compound having the formula:
- ##STR5## wherein R.sup.1 and R.sup.2 are members independently selected from the group consisting of tert-butyl and isopropyl groups;
- and
- R.sup.3 is a member selected from the group consisting of H, lower (C.sub.1 -C.sub.6) alkyls and lower (C.sub.1 -C.sub.4) alkoxys.
Dependencies are inferred from the claim text.