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US 5,308,854 AGranted
Inhibitors of HIV reverse transcriptase
AssigneeMerck & Co., Inc.
InventorsJacob M. Hoffman, Jr., Walfred S. Saari, Clarence S. Rooney, John S. Wai
Life of this patent
Estimating the term…
Abstract
Novel aminopyridones inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Claims4
A compound of the formula:
- ##STR27## wherein:
- X is NH, O, or S;
- Z is O or S;
- n is 1-4;
- R.sub.1 is
- (i) C.sub.1-8 alkyl, unsubstituted or substituted with one or two of C.sub.1-3 alkoxy, halo, C.sub.1-4 alkylamino, C.sub.1-4 -di-alkylamino, or C.sub.1-3 alkylthio;
- (ii) C.sub.1-3 alkylthio;
- (iii) C.sub.1-3 alkoxy;
- or
- (iv) halo;
- R.sub.2 is H, methyl or ethyl, unsubstituted or substituted with one or two of methoxy, methylamino, dimethylamino or methylthio;
- R.sub.3 is H or C.sub.1-8 alkyl;
- --.largecircle. is 2-benzoxazolyl, unsubstituted or substituted with one or more of methyl, halogen or hydroxyl.
10 more elements
Dependencies are inferred from the claim text.