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AssigneeThe Green Cross Corporation
InventorsNaoki Sugiyama, Fumihiko Akaboshi, Haruko Yakumaru, Tomokazu Gotoh, Masanori Sugiura, Shigeki Kuwahara, Masahiko Kajii, Yoshiko Tanaka, Takao Kondoh, Chikara Fukaya
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Aminophenol derivatives of the following formula (I) ##STR1## wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R.sup.8 is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.
An aminophenol derivative which is represented by the formula ##STR33## wherein X is a hydrogen atom, Y.sup.3 is a hydrogen atom or lower alkyl, Z is a hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A.sup.5 is a hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are each an integer of 2 or 3, with the sum of l and m being 4 or 5, E and W are the same or different and each is a nitrogen atom or CH, F is a direct bond or oxygen atom, P and Q are the same or different and each is a hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R.sup.8 is a hydrogen atom, hydroxyl group or a hydroxy-protecting group, or its pharmacologically acceptable salt.
Dependencies are inferred from the claim text.