Pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-Hse
AssigneeSanwa Kagaku Kenkyusho Co., Ltd.
InventorsKiichi Sawai, Masayasu Kurono, Yasuaki Kondo, Makoto Sato, Toshiyuki Kouzaki
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Abstract
There is disclosed a pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-Hse. The composition comprises at least one of organic acids and salts thereof, as a first stabilizer, and pH thereof is adjusted in a range of 5.5-8.0. The composition may contain at least one of substances selected from saccharides, amino acids, proteins and salts thereof, as a second stabilizer. Conversion of [Leu.sup.13 ]-motilin-Hse into [Leu.sup.13 ]-motilin-Hse-lactone is suppressed by increasing pH value and deamidization in asparagine residue at 19-position is suppressed by the presence of the organic acid or salt thereof.
Claims14
A method of stabilizing [Leu.sup.13 ]-motilin-[Hse.sup.23 ] comprising the steps of
- adding a first stabilizer selected from the group consisting of formic acid, acetic acid, propionic acid, butyric acid, tartaric acid, valeic acid, caproic acid, caprylic acid, capric acid, lactic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumalic acid, citric acid and salts thereof, and
- adjusting the pH to between 5.5-8.0.
A pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-[Hse.sup.23 ], comprising an effective amount of [Leu.sup.13 ]-motilin-[Hse.sup.23 ] and at least one stabilizer selected from the group consisting of formic acid, acetic acid, propionic acid, butyric acid, tartaric acid, valeic acid, caproic acid, caprylic acid, capric acid, lactic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumalic acid, citric acid and salts thereof, wherein said pharmaceutical composition has a pH between 5.5-8.0.
Dependencies are inferred from the claim text.