Production of the E. coli LT-B enterotoxin subunit
AssigneePraxis Biologics, Inc.
InventorJohn D. Clements
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Abstract
Methods and compositions are provided for the cloning and expression of genes coding for the non-toxic subunit of the heat-labile enterotoxin (LT-B) of E. coli. The LT-B thus produced may be formulated for use as an immunogen in vaccines. Specific antibodies produced by this invention may be used in diagnostic tests for the detection of Vibrio cholerae or LT positive enterotoxigenic E. coli. The antibodies of this invention may further be formulated into passive vaccines for the prophylactic or therapeutic protection of human beings or other mammalian species against diarrheal diseases caused by Vibrio cholerae or by the LT positive enterotoxigenic E. coli or other bacteria.
Claims2
A substantially pure, non-toxic LT-B subunit of the E. coli heat labile enterotoxin which has the immunological characteristics of the expression product of the DNA encoding said subunit that is contained in plasmid pJC217.
Dependencies are inferred from the claim text.