Catalyst for asymmetric induction
AssigneeSumitomo Chemical Company, Limited
InventorsAtsunori Mori, Shohei Inoue
Life of this patent
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Abstract
A catalyst for asymmetric induction is provided which comprises an amino acid amide derivative represented by the formula [I]: ##STR1## wherein R.sup.1 represents an isopropyl group, etc., R.sup.2 and R.sup.3 are the same or different and each represents a lower alkyl group, etc., R.sup.4 represents a chlorine atom, etc., R.sup.5, R.sup.6 and R.sup.7 are the same or different and each represents a hydrogen atom, etc., and * denotes an abosolute configuration of S or R, and a titanium (IV) alkoxide. Optically active cyanohydrins are obtained in high yield and at high purity by addition of hydrogen cyanide to aldehyde compounds in the presence of the above mentioned catalyst.
Claims18
A catalyst for asymmetric induction comprising the amino acid amide derivative defined below and a titanium (IV) alkoxide, said amino acid amide derivative being represented by the formula (I):
- ##STR4## wherein R.sup.1 represents an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a phenyl group or a benzyl group, R.sup.2 and R.sup.3 are the same or different and each represents a lower alkyl group, a C.sub.3 -C.sub.8 cycloalkyl group, an unsubstituted or substituted phenyl group or a hydrogen atom or R.sup.2 and R.sup.3 may be combined to form a C.sub.3 -C.sub.7 alkylene group, R.sup.4 represents a chlorine atom, a bromine atom, an iodine atom, a lower alkyl group or an unsubstituted or substituted phenyl group, R.sup.5, R.sup.6 and R.sup.7 are the same or different and each represents a hydrogen atom, a halogen atom, a methyl group or a methoxy group or R.sup.5 and R.sup.6 or R.sup.6 and R.sup.7 may be combined to form CH.dbd.CH--CH.dbd.CH or OCH.sub.2 O and * denotes an absolute configuration of S or R, wherein the substituted phenyl group of R.sup.2, R.sup.3 and R.sup.4 each contains a substituent selected from the group consisting of a halogen atom, a C.sub.1 -C.sub.4 alkyl group and a C.sub.1 -C.sub. 4 alkoxy group.
Dependencies are inferred from the claim text.