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US 5,308,614 AGranted
Methods for the production of antibodies and induction of immune responses to tumor-associated gangliosides by immunization with ganglioside lactones
AssigneeThe Biomembrane Institute
InventorSen-Itiroh Hakomori
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Abstract
The present invention relates to an improved method for the production of antibodies to tumor-associated gangliosides using ganglioside lactones. The resulting antibodies are useful in the detection and treatment of tumors containing gangliosides. The present invention also relates to methods of treatment of tumors by active immunization using ganglioside lactones.
Claims5
A method for inducing an immune response to a tumor-associated ganglioside comprising administering to a subject a composition consisting essentially of:
- (a) an immunogenically effective amount of an isolated lactone of a tumor-associated ganglioside;
- and
- (b) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.