Skin adhesive hydrogel, its preparation and uses
AssigneePaper Manufactures Company
InventorDonald H. Lorenz
Life of this patent
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Abstract
A skin adhesive hydrogel formed by mixing in aqueous medium: (A) major proportion of a high molecular weight water-soluble polyvinylpyrrolidone having ring opened pyrrolidone groups and (B) a minor proportion of a water-soluble multifunctional amine-containing polymer to form a water insoluble, water swellable cross-linked salt between carboxyl groups of the ring opened pyrrolidone groups and basic amine groups of the polyfunctional amine-containing polymer. The reaction is advantageously carried out in the presence of a plasticizer.
Claims22
A skin adhesive hydrogel composition comprising a water-insoluble, water-swellable cross-linked ampholyte salt of
- A. a high molecular weight water-soluble polyvinylpyrrolidone having ring opened pyrrolidone groups providing at least 1.5.times.10.sup.-2 milliequivalents of carboxylic acid groups per gram of polymer, and
- B. a water-soluble multifinctional amine-containing polymer selected from the group consisting of polyethyleneimine, amine-terminated polyethylene oxide, amine-terminated polyethylene/polypropylene oxide, polymers of dimethyl amino ethyl methacrylate and copolymers of dimethyl amino ethyl methacrylate and vinyl pyrrolidone.
The method of making a polymer for skin adhesive hydrogel which comprises mixing in aqueous medium
- A. a high molecular weight water-soluble polyvinylpyrrolidone having ring opened pyrrolidone groups providing at least 1.5.times.10 milliequivalents of carboxylic acid groups per gram of polymer, and
- B. a water-soluble multifunctional amine-containing polymer selected from the group consisting of polyethyleneimine, amine terminated polyethylene oxide, amine terminated polyethylene/polypropylene oxide, polymers of dimethyl amino ethyl methacrylate and copolymers of dimethyl amino ethyl methacrylate and vinyl pyrrolidone until reaction between acid groups of the ring opened polyvinyl-pyrrolidone and basic amine groups of the water-soluble multifunctional amine-containing polymer form a water-insoluble, water-swellable cross-linked ampholyte salt.
Dependencies are inferred from the claim text.