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US 5,306,500 AGranted
Method of augmenting tissue with collagen-polymer conjugates
AssigneeCollagen Corporation
InventorsWoonza Rhee, Donald G. Wallace, Alan S. Michaels, Ramon A. Burns, Jr., Louis Fries, Frank DeLustro, Hanne Bentz
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Abstract
Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
Claims14
A method for augmenting tissue in a mammal, which comprises:
- administering at a site in need of augmentation a composition comprising
- collagen chemically conjugated to a synthetic hydrophilic polymer, and
- a sufficient amount of a fluid, pharmaceutically acceptable carrier.
A method for augmenting tissue in a mammal, which comprises:
- administering at a site in need of augmentation a composition comprising
- collagen;
- a synthetic hydrophilic polymer having a first and second end, wherein said first and second ends each comprise a reactive group capable of forming a covalent bond in situ with an available lysine side chain present in collagen;
- and
- a fluid pharmaceutically acceptable carrier in an amount sufficient to form an injectable composition.
2 more elements
Dependencies are inferred from the claim text.