Method for detecting trace contaminants
AssigneePerSeptive Biosystems, Inc.
InventorNoubar B. Afeyan
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Abstract
The invention features a method of detecting a trace solute in a solution which contains a major amount of a dissolved product, the method including the steps of: flowing the solution through means for extracting the product to produce an effluent flow substantially free of product containing the trace solute; flowing the effluent through a trace solute adsorbing means to progressively accumulate therein the trace solute; and eluding the trace solute from the adsorber to produce an eluant fraction containing a detectable quantity of the trace solute.
Claims8
A method of detecting a trace solute in a solution comprising a major amount of a dissolved product, the method comprising the steps of:
- flowing the solution through product extraction means comprising a chromatography matrix which selectively extracts the product without substantially extracting said trace solute thereby to produce an effluent, substantially free of said product and containing said trace solute, which flows through and exits from said extraction means;
- flowing said effluent exiting said product extraction means through a trace solute adsorbing means to progressively accumulate therein said trace solute;
- and
- eluting said trace solute from said adsorbing means to produce an eluant fraction containing a detectable quantity of said trace solute.
Dependencies are inferred from the claim text.