Resorufin derivatives
AssigneeBoehringer Mannheim GmbH
InventorsChristian Klein, Hans-Georg Batz, Rupert Herrmann
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Abstract
The present invention provides resorufin derivatives of the general formulae: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which can be the same or different, are hydrogen, halogen, carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups or lower alkyl or lower alkoxy radicals, which can be substituted by carboxyl, carboxamido, lower alkoxycarbonyl, cyano or nitro groups, and wherein R.sup.4 and R.sup.5 can together also represent an anellated aromatic residue, Z is a bridge member, A is the residue of a ligand and n is a whole number of from 1 to 200. The present invention also provides processes for the preparation of these resorufin derivatives, as well as intermediates for the preparation thereof.
Claims8
A colored or fluorescent resorufin derivative designated resorufin-4-carboxylic acid piperazide or 8-chlororesorufin-4-carboxylic acid piperazide.
A colored or fluorescent resorufin derivative designated N-(4-resorufinylcarbonyl)-piperidine-4-carboxylic acid-N'-hydroxysuccinimide ester.
A colored or fluorescent resorufin derivative designated 6-methylresorufin-4-carboxylic acid piperazide trifluoroacetate.
A colored or fluorescent resorufin derivative designated 8-ethylresorufin-4-carboxylic acid (1-dephenylhydantoinylmethylcarbonyl)-piperazide.
A colored or fluorescent resorufin derivative designated 8-chlororesorufin-4-carboxylic acid piperazide trifluoroacetate.
A colored or fluorescent resorufin derivative designated 8-chlororesorufin-1-carboxylic acid piperazide trifluoroacetate.
A colored or fluorescent resorufin derivative designated resorufin-4-carboxylic acid (tert-butoxycarbonylmethyl)-methylamide.
A colored or fluorescent resorufin derivative designated 9-hydroxy-benzophenoxazone-8-carboxylic acid piperazide trifluoroacetate.
Dependencies are inferred from the claim text.