DNA sequence encoding a selectin ligand
AssigneesGenentech, Inc., The Regents of the University of California
InventorsLaurence A. Lasky, Yasuyuki Imai, Steven D. Rosen, Mark S. Singer
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Abstract
The invention relates to glycoprotein ligands of selectins. The invention further relates to methods and means for preparing and to nucleic acids encoding these ligands. The invention further concerns a method of treating a symptom or condition associated with excessive binding of circulating leukocytes to endothelial cells by administering to a patient in need of such treatment a glycoprotein ligand of a selectin.
Claims20
An isolated nucleic acid molecule comprising a nucleotide sequence able to hybridize under low stringency conditions to the complement of a nucleotide sequence encoding a protein having the amino acid sequence shown in FIG. 4, and encoding a protein possessing an effector function or antigenic property of a naturally occurring selectin ligand.
The host cell of claim 19 which is from the human embryonic kidney cell line 293S.
An isolated nucleic acid molecule, selected from the group consisting of:
- (a) a cDNA clone comprising a nucleotide sequence encoding amino acids 42 to 63, or 93 to 122 of the amino acid sequence shown in FIG. 4;
- and
- (b) a DNA molecule able to hybridize under low stringency conditions to a clone of (a).
Dependencies are inferred from the claim text.