Pharmaceutical bacteriocin compositions and methods for using the same
AssigneeApplied Microbiology, Inc.
InventorsPeter Blackburn, Steven J. Projan, Edward B. Goldberg
Life of this patent
Estimating the term…
Abstract
Compositions comprising lanthionine-containing bacteriocins such as nisin act as bactericides under conditions such as those found in the gastrointestinal tract. In a preferred embodiment pharmaceutical preparations containing the compositions are used for the control of bacteria responsible for disorders of the gastrointestinal tract.
Claims37
A method of preventing or treating gastrointestinal bacterial infection due to the presence of pathogenic bacteria comprising contacting the bacteria with an effective amount of a lanthionine-containing bacteriocin in a suitable carrier and a chelator.
A method of preventing or treating gastrointestinal disorders comprising administering into the gastrointestinal tract a composition comprising a lanthionine-containing bacteriocin.
A pharmaceutical composition useful for treating gastrointestinal disorders resulting from gram negative bacteria comprising an effective amount of a lanthionine-containing bacteriocin, an effective amount of a pharmaceutically active substance selected from the group consisting of bismuth salts, cimetidine, ranitidine, omeprazole, antacids, and urease inhibitors, and a pharmaceutically acceptable carrier.
A method of containing or treating gastrointestinal disorders due to the presence of a pathogenic microorganism comprising contacting the microorganism with a composition comprising a lanthionine-containing bacteriocin and a chelator in a suitable vehicle.
A pharmaceutical composition useful for treating gastrointestinal disorders due to undesirable microorganisms comprising a suitable amount of a lanthionine-containing bacteriocin, a chelator and a pharmaceutically acceptable carrier.
A method of preventing or treating gastrointestinal bacterial infection resulting form Helicobacter pylori or Campylobacter jejuni bacteria comprising contacting the bacteria with an effective amount of nisin in a pharmaceutically acceptable carrier and a chelator.
A method of preventing or treating Helicobacter pylori bacteria colonization of dental plaque comprising contacting the bacteria with an effective amount of lantionine-containing bacteriocin in a suitable carrier and a chelator.
A method of preventing or treating Helicobacter pylori bacteria colonization of the gastrointestinal tract comprising contacting the bacteria in dental plaque with an effective amount of a lanthionine-containing bacteriocin in a suitable carrier and a chelator.
A method of simultaneously preventing or treating Helicobacter pylori bacteria colonization of dental plaque and the gastrointestinal tract comprising contacting the bacteria with an effective amount of a lantionine-containing bacteriocin in a suitable carrier and a chelator.
A method of treating gastrointestinal infections of Helicobacter pylori which comprises administering to a patient in need thereof an effective amount of a composition comprising a lantionine-containing bacteriocin and a chelating agent in combination with an effective amount of a composition comprising a pharmaceutically active substance selected from the group consisting of a bismuth salt, cimetidine, ranitidine, omeprazole, antacid, and urease inhibitor.
Dependencies are inferred from the claim text.