Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
AssigneeBoard of Regents, The University of Texas System
InventorsJoseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething
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Abstract
The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
Claims4
A mutant of t-PA, wherein said mutant, the phenylalanine at position 305 of t-PA has been replaced by a basic amino acid, and the alanine at position 292 of t-PA has been replaced by serine.
Dependencies are inferred from the claim text.