Pulmonary surfactant protein fragments
AssigneeAbbott Laboratories
InventorsVirender K. Sarin, Jack L. Fox, Shanker L. Gupta, Darryl R. Absolom
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Abstract
This invention discloses that certain fragments of a pulmonary surfactant protein exhibit unexpected surface activity. These protein fragments are useful in preparing formulations for the treatment of respiratory disease.
Claims18
A composition of matter which comprises a fragment of the SP-B protein which exhibits surfactant activity when admixed with lipids in a weight ratio of said peptide to said lipid of not less than 1:5,000, said SP-B fragment consisting essentially of the amino acid sequence:
- ##STR7##
A method for treating hyaline membrane disease or other syndromes caused by having insufficient or abnormal surfactant material, said method comprising administration of an effective amount of a surfactant composition to a patient in need of treatment, said surfactant composition comprising the SP-B fragment admixed with lipids in a weight ratio of said peptide to said lipid of not less than 1:5,000, said SP-B fragment consisting essentially of the amino acid sequence:
- ##STR8##
A method for pulmonary drug delivery, said method consisting of administering to a patient in need of said drug therapy, a therapeutically effective amount of a composition comprising:
- 1) the SP-B protein fragment admixed with 2) lipids in a weight ratio of said peptide to said lipid of not less than 1:5,000, and 3) an appropriate therapeutic agent, said SP-B fragment consisting essentially of the amino acid sequence:
- ##STR9##
A composition of matter which comprises a fragment of the SP-B protein which exhibits surfactant activity when admixed with lipids wherein said peptide comprises not less than 200 parts per million of said peptide-lipid composition, said SP-B fragment consisting essentially of the amino acid sequence:
- ##STR10##
A method for treating hyaline membrane disease or other syndromes caused by having insufficient or abnormal surfactant material, said method comprising administration of an effective amount of a surfactant composition to a patient in need of treatment, said surfactant composition comprising the SP-B fragment admixed with lipids wherein said peptide comprises not less than 200 parts per million of said peptide-lipid composition, said SP-B fragment consisting essentially of the amino acid sequence:
- ##STR11##
A method for pulmonary drug delivery, said method consisting of administering to a patient in need of said drug therapy, a therapeutically effective amount of a composition comprising:
- 1) the SP-B protein fragment admixed with 2) lipids in a weight ratio of said peptide comprises not less than 200 parts per million of said protein-lipid composition;
- and 3) an appropriate therapeutic agent, said SP-B fragment consisting essentially of the amino acid sequence:
- ##STR12##
Dependencies are inferred from the claim text.