Method and device for the release of drugs to the skin
AssigneeNoven Pharmaceuticals, Inc.
InventorsSteven Sablotsky, Joseph A. Gentile
Life of this patent
Estimating the term…
Abstract
A method of increasing the adhesiveness of a shaped pressure sensitive adhesive, comprising adding an adhesiveness and drug release increasing amount of a clay to said adhesive prior to casting of the adhesive. A dermal composition comprising a drug, a pressure sensitive adhesive, an adhesiveness increasing amount of a clay and a solvent. A dermal composition comprising a drug, a multipolymer of ethylene vinyl acetate, an acrylic polymer, a natural or synthetic rubber and a clay, along with optional ingredients known for use in transdermal drug delivery systems.
Claims36
A method of increasing the adhesiveness of a pressure sensitive adhesive composition comprising an admixture of a natural or synthetic rubber and a multipolymer comprising a ethylene/vinyl acetate polymer and an acrylic polymer, in which the ratio by weight of the ethylene/vinyl acetate polymer to the acrylic polymer is about 1:20 to about 20:1 and the ratio by weight of the multipolymer to the rubber is about 1:10 to about 30:1.
- said method comprising the step of admixing said rubber, said acrylic polymer, said ethylene/vinyl acetate polymer, a drug, and at least one clay, wherein the resulting composition comprises an adhesiveness increasing amount of clay, said amount of clay being from about 0.1 to about 20% by weight of said resulting composition, wherein the clay is a natural or synthetic clay selected from the group consisting of hydrated aluminum silicate, kaolinite, montmorillonite, atapulgite, illite, bentonite, and halloysite.
A dermal composition comprising an admixture of a drug, a pressure sensitive adhesive composition comprising a natural or synthetic rubber, and a multipolymer comprising a ethylene/vinyl acetate polymer and an acrylic polymer, in which the ratio by weight of the ethylene/vinyl acetate polymer to the acrylic polymer is about 1:20 to about 20:1, and the ratio by weight of the multipolymer to the rubber is about 1:10 to about 30:1, and further comprising from about 0.1 to about 20% by weight of an adhesiveness increasing amount of at least one natural or synthetic clay selected from the group consisting of hydrated aluminum silicate, kaolinite, montmorillonite, atapulgite, illite, bentonite, and halloysite.
The composition of claim 19, in which the steroid is 17 .beta.-estradiol and the clay is bentonite.
Dependencies are inferred from the claim text.