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US 5,298,657 AGranted
Preparation of substituted guanidines
AssigneeCambridge NeuroScience, Inc.
InventorsGraham J. Durant, Sharad S. Magar
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Abstract
A process for the preparation of a substituted guanidine by reacting a substituted cyanamide with ammonia or a substituted amine in the presence of a Lewis acid catalyst. Also disclosed is a process for the preparation of a tri-substituted guanidine by reacting a mono-substituted cyanamide with a di-substituted amine.
Claims23
A process for the preparation of a substituted guanidine which comprises the step of reacting a substituted cyanamide with ammonia or a substituted amine in the presence of a Lewis acid catalyst.
Dependencies are inferred from the claim text.