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US 5,298,643 AGranted
Aryl imidate activated polyalkylene oxides
AssigneeEnzon, Inc.
InventorRichard B. Greenwald
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Abstract
Water-soluble aryl imidate activated polyalkylene oxides having improved hydrolytic stability and conjugates of the aryl imidate activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of preparing the activated polyalkylene oxides and conjugates thereof are also disclosed.
Claims8
A water-soluble aryl imidate activated polyalkylene oxide having a structure represented by (I):
- ##STR5## wherein R is a water-soluble polyalkylene oxide;
- L is NHC(O), such that the carbonyl is attached to the phenyl ring;
- R.sub.1 is a moiety selected from the group consisting of alkyl, phenyl, phenylalkyl and cycloalkyl moieties;
- and
- X is a terminal moiety of said polyalkylene oxide selected from the group consisting of OH, C.sub.1-4 alkoxy moieties and aryl imidates corresponding to the structure:
- ##STR6## wherein L and R.sub.1 are defined as above.
3 more elements
Dependencies are inferred from the claim text.