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AssigneeSterling Winthrop Inc.
InventorsGeorge C. Na, Natarajan Rajagopalan
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This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and an anionic or cationic surfactant as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is tyloxapol. Preferred anionic surfactants are dioctylsulfonesuccinate, sodium dodecyl sulfate and sodium oleate. Preferred cationic surfactants are dodecyltrimethylammonium bromide and cetrimide tetradecyl ammonium bromide. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and an anionic or cationic surfactant as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
A compound comprised of nanoparticles consisting essentially of a crystalline diagnostic or therapeutic agent and a non-crosslinked nonionic surfactant adsorbed on the surface thereof and an anionic or cationic cloud point modifier associated therewith, which cloud point modifier is present in an amount of 0.005-20% by weight based on the total weight of the composition and sufficient to increase the cloud point of the surface modifier, wherein said nanoparticles are resistant to particle size growth when said composition is heat sterilized at 121.degree. C. for 15 minutes.
A method for of making nanoparticles having a surface modifier adsorbed on the surface and an anionic or cationic cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.
Dependencies are inferred from the claim text.