Shaped, swollen demineralized bone and its use in bone repair
AssigneeOsteotech, Inc.
InventorsAnnamarie B. Prewett, Roger C. Stikeleather, Simon Bogdansky, Robert K. O'Leary
Life of this patent
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Abstract
A shaped piece of swollen demineralized bone which can also be plasticized is provided for use in surgical bone repair.
Claims30
A shaped piece of swollen demineralized bone having substantially regular geometry and/or greater than 12 mm. in size along at least one dimension thereof, the bone being combined with a biocompatible swelling agent,
- wherein the swelling agent is selected from the group consisting of ethylene glycol, diethylene glycol, triethylene glycol, 1,2-propanediol, trimethylolethane, trimethylopropane, erythritol, pentaerythritol, polyethylene glycols, xylitol, sorbitol, mannitol, dulcitol, arabinose, xylose, ribose, adonitol, arabitol, rhamose, inositol, fructose, galactose, glucose, mannose, sorbose, sucrose, maltose, lactose, maltitol, lactitol, stachyose, maltopentaose, cyclomaltohexaose, carrageenan, agar, alginic acid, guar gum, gum tragacanth, locust bean gum, gum arabic, xanthan gum, amylose and mixtures thereof.
A shaped piece of a swollen demineralized bone having substantially regular geometry and/or greater than 12 mm. in size along at least one dimension thereof, the bone being combined with a biocompatible swelling agent,
- wherein the swelling agent is selected from a member of the group consisting of liquid polyhydroxy compound, liquid polyhydroxy compound ester, liquid solution of solid polyhydroxy compound, liquid solution of solid polyhydroxy compound ester and mixtures thereof, and
- the polyhydroxy compound is selected from the group consisting of acyclic polyhydric alcohols, non-reducing sugars, sugar alcohols, sugar acids, monosaccharides, disaccharides, water-soluble or water dispersible oligosaccharides, polysaccharides, polyalkylene glycols and mixtures thereof.
A shaped piece of swollen demineralized bone having substantially regular geometry and/or greater than 12 mm. in size along at least one dimension thereof, the bone being combined with a biocompatible swelling agent and in the form of a sheet, ring, disk, cube, cylinder or tube,
- wherein the biocompatible swelling agent is selected from the group consisting of acyclic polyhydric alcohols, non-reducing sugars, sugar alcohols, sugar acids, monosaccharides, disaccharides, water-soluble or water dispersible oligosaccharides, polysaccharides, polyalkylene glycols, known esters of any of the foregoing and mixtures thereof.
A method of preparing a shaped piece of osteogenic bone having substantially regular geometry and/or greater than 12 mm. in size along at least one dimension thereof, for application to a bone defect site to promote new bone growth at the site, comprising
- a) demineralizing bone tissue, and
- b) swelling the demineralized bone tissue by combining with a swelling agent selected from the group consisting of acyclic polyhydric alcohols, non-reducing sugars, sugar alcohols, sugar acids, monosaccharides, disaccharides, water-soluble or water dispersible oligosaccharides, polysaccharides, polyalkylene glycols, known esters of any of the foregoing and mixtures thereof.
A shaped piece of swollen demineralized bone having substantially regular geometry and/or greater than 12 mm. in size along at least one dimension thereof, the bone being combined with a biocompatible swelling agent,
- wherein the swelling agent is selected from a member of the group consisting of liquid polyhydroxy compound, liquid polyhydroxy compound ester, liquid solution of solid polyhydroxy compound, liquid solution of solid polyhydroxy compound ester and mixtures thereof, and
- the polyhydroxy compound possesses from 2 to about 18 carbon atoms and is selected from the group consisting of acyclic polyhydric alcohols, non-reducing sugars, sugar alcohols, sugar acids, monosaccharides, disaccharides, water-soluble or water dispersible oligosaccharides, polysaccharides, polyalkylene glycols and mixtures thereof.
Dependencies are inferred from the claim text.