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AssigneeKanegafuchi Kagaku Kogyo Kabushiki Kaisha
InventorsYoshiaki Yano, Shigeki Masuda, Takayoshi Hidaka
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The present invention is directed to a stable pharmaceutical composition wherein the absorbability of a lipophilic drug which is insoluble or practically insoluble in water or another drug such as a bioactive peptide in oral administration has been improved to such extent that a high level of blood concentration can be retained, and to a method for producing such a stable pharmaceutical composition. The pharmaceutical composition of the present invention offers improvements in the absorbability, for example, a high level of blood concentration can be retained for a long time in oral administration because it is highly resistant to lipase. Also, the pharmaceutical composition is highly safe because the emulsifier used is derived from mammalian milk.
A method for producing a pharmaceutical composition comprising the steps of emulsifying a pharmaceutically effective amount of a lipophilic drug with a fat globule membrane of mammalian milk and centrifuging it under two different sets of centrifugal conditions so as to obtain a desired grain size fraction of about 1-5 .mu.m by fractionation;
Dependencies are inferred from the claim text.