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US 5,296,615 AGranted
Process and intermediates for chiral epoxides
AssigneeEli Lilly and Company
InventorLeland O. Weigel
Life of this patent
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Abstract
Chiral epoxybutyrates are prepared in high yield from novel dihydro-3R-substituted sulfonyloxy-4R-hydroxy-2-(3H)furanones via based catalyzed alcoholysis. The product chiral epoxy butyrates are useful intermediates for the synthesis of 1-carba-1-dethia cephem antibiotics.
Claims3
A compound of the formula ##STR5## wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl, trifluoromethyl, benzyl, phenyl or tolyl.
Dependencies are inferred from the claim text.