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US 5,296,608 AGranted
Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides
AssigneeHoffman-La Roche Inc.
InventorsWaleed Danho, Jefferson W. Tilley, Joseph Triscari, Rolf Wagner
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Abstract
Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.
Claims15
A compound of the formula:
- ##STR42## wherein one of A' or B' is a group of the formula:
- ##STR43## and the other of A' or B' is H wherein R.sub.0 is H or F, R.sub.2 is H, lower alkenyl, or substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups, and r is an integer from 0-2;
- R' is H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups;
- ##STR44## wherein R.sub.3 and R.sub.4 are H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups, and each R.sub.5 is independently H, lower alkyl, or both groups R.sub.5 taken together are a six membered ring which may be aromatic.
1 more element
Dependencies are inferred from the claim text.