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US 5,296,606 AGranted
O-(3-amino-2-hydroxypropyl)-hydroximic acid halides and process for preparing the same
AssigneeBiorex Kutato-Fejleszto KFT
InventorsPeter L. Nagy, Bela Balazs, Maria Boross, Jeno Szilbereky, Gizella Zsila, Lajos braham, Gyorgy Blasko, Bela Gachalyi, Attila Almasi, Gabor Nemet
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Abstract
Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.
Claims1
Hydroximic acid derivatives of formula (VIII) ##STR2## and the salts thereof wherein X is selected from the group consisting of fluoro, chloro, bromo and iodo,
- R.sup.1 and R.sup.2 when taken together with the nitrogen to which these are attached form a 5 to 8 membered saturated ring,
- R.sup.3 is hydrogen, phenyl, naphthyl or pyridyl optionally substituted with one or more halo or alkoxy,
- R.sup.4 is hydrogen or phenyl,
- R.sup.5 is hydrogen or phenyl,
- m is 0, 1 or 2 and
- n is 0, 1 or 2.
3 more elements
Dependencies are inferred from the claim text.