Process for producing carboxylic acid esters
AssigneeNihon Nohyaku Co., Ltd.
InventorsKeiji Suto, Masaaki Kudo, Moriharu Yamamoto
Life of this patent
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Abstract
A process for producing a carboxylic acid ester, which comprises reacting an organic chloride having at least one chlorine atom on its ring of a substituted or unsubstituted, aromatic or heterocyclic hydrocarbon with carbon monoxide and an amine or an alcohol in the presence of a base by using as catalysts a palladium compound and a phosphine compound represented by the general formula (V): (R).sub.2 P--X--P(R).sub.2 (V) wherein R is an alkyl group or a substituted or unsubstituted phenyl group, and X is an alkylene group having 1 to 6 carbon atoms, ##STR1## or a binaphthyl group.
Claims7
A process for producing a carboxylic acid ester represented by the general formula (I-2)
- R.sup.1.(COOR.sup.4)m (I-2)
- wherein R.sup.1 is a phenyl or substituted phenyl group with substituents selected from the group consisting of halogen atom, alkyl group having 1 to 3 carbon atoms, haloalkyl group having 1 to 3 carbon atoms, cyano group, nitro group, hydroxy group, alkoxy group having 1 to 3 carbon atoms, alkylthio group having 1 to 3 carbon atoms, alkylcarbonyl group having 1 to 3 carbon atoms or amino group, said R.sup.1 further being phenoxyphenyl group, benzoylphenyl group, phenylsulfonylphenyl group, biphenyl group, hydroxybiphenyl group, thienyl group, furyl group, pyridyl group, picolinyl group, quinolinyl group and quinoxalinyl group;
- R.sup.4 is an alkyl group having 1 to 8 carbon atoms, phenyl group, cresyl group, xylenyl group, benzyl group, cinnamyl group, furfuryl group or thienyl group;
- and m is an integer of 1 to 4;
- said process comprising the steps of reacting an aromatic chloride represented by the general formula (IV)
- R.sup.1.(C1)m (IV)
- wherein R.sup.1 and m have the same meaning as defined above, carbon monoxide and an alcohol represented by the general formula (II)
- R.sup.4.OH (II)
- wherein R.sup.4 have the same meaning as defined above, in the presence of a base and catalysts consisting of a palladium compound and a phosphine compound having the general formula (V)
- (R).sub.2 P--X--P(R).sub.2 (V)
- wherein R is an alkyl group having 1 to 4 carbon atoms or a phenyl group, and X is an alkylene group having 1 to 6 carbon atoms, ##STR27## or a binaphthyl group;
- said reaction being conducted under conditions that temperature and pressure are sufficient to induce reaction.
Dependencies are inferred from the claim text.