Pyrrolopyrimidine derivatives, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsAkimoto Hiroshi, Takenori Hitaka, Tetsuo Miwa
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Abstract
A compound of the formula ##STR1## wherein the ring A pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, --COOR.sup.1 and --COOR.sup.2 are independently carboxyl groups which may be esterified and n is an integer of 2 to 4, and R may be different in each of the n repeating units, and salts thereof have excellent antitumor effects, and can be used as antitumor agents in mammals.
Claims15
A compound of the formula ##STR12## wherein the ring A is a pyrrole or pyrroline ring, X is an amino group or a hydroxyl group, Y is a hydrogen atom, an amino group or a hydroxyl group, R is a hydrogen atom, a fluorine atom, a C.sub.1-3 alkyl group, a C.sub.2-3 alkenyl group or a C.sub.2-3 alkynyl group, and n is an integer of 2 to 4, and R may be different in each of the n repeating units, or a salt or a C.sub.1-3 alkyl, benzyl, nitrobenzyl, methoxybenzyl, phenyl, nitrophenyl or methoxyphenyl ester at the carboxyl group thereof.
Dependencies are inferred from the claim text.