Calcification-resistant synthetic biomaterials
AssigneeUniversity of Michigan
InventorRobert J. Levy
Life of this patent
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Abstract
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Illustratively, reaction conditions utilizing bi- or polyfunctional epoxides result in epoxide bridge incorporation of the anticalcification agent to the biomaterial elastomer.
Claims8
A method of making a calcification-resistant bicompatible polymeric material comprising the steps of:
- forming a monoadduct of a polyphosphonate anticalcification agent and a reactive polyfunctional epoxide;
- adding the monoadduct to a prepolymer base of a biocompatible copolymer;
- adding the second component of the biocompatible copolymer;
- and
- polymerizing.
A method of making a calcification-resistant polymeric material comprising the steps of:
- forming a solution of a polyphosphonate anticalcification agent and a reactive polyfunctional epoxide in a solvent;
- adding to the solution a prepolymerized biocompatible polymer which is soluble in the solvent to form a mixture;
- and
- polymerizing the mixture.
Dependencies are inferred from the claim text.