Guanidine compounds
AssigneeAdir et Compagnie
InventorsCharles Malen, Jean-Michel Lacoste, Guillaume de Nanteuil
Life of this patent
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Abstract
A compound of formula (I): ##STR1## in which: R.sub.1 represents substituted or unsubstituted phenyl or (C.sub.3 -C.sub.7) cycloalkyl, R.sub.2 represents trifluoromethyl or (C.sub.3 -C.sub.4) cycloalkyl, A represents --CH.sub.2 --, --CH.dbd.N--, .dbd.N-- or --NH--, R.sub.3 and R.sub.4, which may be identical or different, represent hydrogen or linear or branched (C.sub.1 -C.sub.6) alkyl or, with the nitrogen atoms to which they are attached, form a 5- or 6-membered heterocycle, R represents either hydrogen in the case where A=--CH.sub.2 --, --CH.dbd.N-- or --NH--, or a bond of the group A when the latter is equal to .dbd.N--, its enantiomers and epimers as well as its addition salts with a pharmaceutically acceptable acid.
Claims11
A compound selected from those of formula (I):
- ##STR15## in which:
- R.sub.1 represents--phenyl optionally substituted with one or more halogen, linear or branched (C.sub.1 -C.sub.6) alkyl, hydroxyl, or linear or branched (C.sub.1 -C.sub.6) alkoxy;
- or C.sub.3 -C.sub.7 cycloalkyl,
- R.sub.2 represents trifluoromethyl or C.sub.3 -C.sub.4 cycloalkyl,
- A represents --CH.dbd.N--, .dbd.N--, or --NH--,
- R.sub.3 and R.sub.4, together with the nitrogen atoms to which they are attached, form a 5-membered heterocycle,
- R represents hydrogen in the case where A represents --CH.dbd.N-- or --NH--, or a bond selected from these of the group A when A represents .dbd.N--, with the proviso, however, that when A is .dbd.N-- and R.sub.1 is a phenyl optionally substituted, R.sub.2 does not represent a cycloalkyl (C.sub.3 -C.sub.4),
- its enantiomers and epimers as well as its addition salts with a pharmaceutically-acceptable acid.
A compound as claimed in claim wherein R.sub.2 represents trifluoromethyl, its enantiomers and epimers as well as its addition salts with a pharmaceutically acceptable acid.
Dependencies are inferred from the claim text.