Pyrrolidine compounds having thromboxane A.sub.2 receptor antagonistic activity and thromboxane A.sub.2 synthase inhibiting activity

A compound selected from those of formula (I):

• ##STR16## in which:
• R.sub.1 represents:
• linear or branched (C.sub.1 -C.sub.6) alkyl, unsubstituted or substituted with 2-pyridyl, 3-pyridyl, or phenyl (itself optionally substituted with one or more halogen or linear or branched (C.sub.1 -C.sub.6) alkyl, linear or branched (C.sub.1 -C.sub.6) alkoxy or trihalomethyl),
• phenyl, unsubstituted or substituted with one or more hydrogen or linear or branched (C.sub.1 -C.sub.6) alkyl, linear or branched (C.sub.1 -C.sub.6) alkoxy or trihalomethyl,
• pyridyl,
• phenylsulfonyl, unsubstituted or substituted on the phenyl ring with one or more halogen or linear or branched (C.sub.1 -C.sub.6) alkyl, linear or branched (C.sub.1 -C.sub.6) alkoxy or trihalomethyl,
• linear or branched ##STR17## linear or branched ##STR18## benzoyl (unsubstituted or substituted on the phenyl ring with one or more halogen, hydroxyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, or trifluoromethyl) or pyridylcarbonyl,
• C.sub.1 -C.sub.6 alkylaminocarbonyl or phenylaminocarbonyl (unsubstituted or substituted on the phenyl ring with one or more halogen, hydroxyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, or trifluoromethyl), ##STR19## R.sub.2 represents:
• phenyl, unsubstituted or substituted with one or more halogen or linear or branched (C.sub.1 -C.sub.6) alkyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, hydroxyl or trihalomethyl,
• 3-pyridyl or 2-pyridyl,
• R.sub.3 represents any one of the following groups:
• ##STR20## in which m is equal to 2, 3 or 4,
• n is equal to 4, 5, 6, or 7,
• and R represents hydrogen or a linear or branched (C.sub.1 -C.sub.6) alkyl,
• its enantiomers, diastereoisomers and epimers, as well as its addition salts with a pharmaceutically-acceptable acid or base.