1-substituted-2-(N-pheny l-N-(phenylmethyl)methanamine)-4,5-dihydro-imidazoles and related compounds and their use in treating calcium overload in brain cells

The method of treating an indication relating to or arising from Ca overload in brain cells comprising the step of administering to a person in need of treatment an effective Ca overload-blocking amount of a compound having the formula ##STR17## wherein R.sup.1 is C.sub.1-10 -alkyl which is unbranched or branched;

• C.sub.2-10 -alkenyl or ##STR18## wherein R'" is H or ##STR19## R.sup.2 is phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl;
• benzyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 -C.sub.1-6 -alkyl, methyl;
• or cyclohexyl;
• R.sup.3 phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl;
• naphthyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl;
• C.sub.1-6 unsaturated alkyl;
• R.sup.4 is H, C.sub.1-6 -alkyl, or benzyl;
• R' and R" are each hydrogen
• or a pharmaceutically-acceptable addition salt thereof.

A pharmaceutical preparation for the treatment of an indication relating to or arising from Ca overload in brain cells comprising an effective Ca overload-blocking amount of a compound of the formula ##STR20## wherein R.sup.1 is C.sub.1-10 -alkyl which is unsubstituted or branched;

• C.sub.2-10 -alkenyl or ##STR21## wherein R'" is H or ##STR22## R.sup.2 is phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl;
• benzyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 -C.sub.1-6 -alkyl, methyl;
• or cyclohexyl;
• R.sup.3 phenyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl;
• naphthyl which is unsubstituted or substituted one or more times with halogen, CF.sub.3, C.sub.1-6 -alkoxy, NO.sub.2, CO.sub.2 --C.sub.1-6 -alkyl, methyl;
• C.sub.1-6 unsaturated alkyl;
• R.sup.4 is H, C.sub.1-6 -alkyl, or benzyl;
• R' and R" are each hydrogen
• or a pharmaceutically-acceptable addition salt thereof, and a pharmaceutically-acceptable carrier or diluent therefor.