Certain chroman derivatives useful for treating symptoms caused by contraction of smooth muscles, circulatory diseases or epilepsy

A method for treating the symptoms caused by contraction of smooth muscles, the diseases of the circulatory system or epilepsy which comprises administering to mannals an effective quantity of a chroman derivative represented by general formula (1):

• ##STR8## wherein R.sub.1 represents cyano group, nitro group, halogenomethyl group or --SO.sub.2 --X group (X represents lower alkyl group having 1-6 carbon atoms or aryl group);
• R.sub.2 represents hydrogen atom or OA group (A represents hydrogen atom, nitro group, lower acyl group having 1-6 carbon atoms, arylcarbonyl group, lower alkylsulfonyl group having 1-6 carbon atoms, arylsulfonyl group, arylalkyl group, tetrahydropyranyl group, lower alkoxycarbony group having 1-6 carbon atoms, arylalkoxycarbonyl group or silyl derivative group);
• R.sub.3 singly represents a hydrogen atom;
• or R.sub.3 forms a bond jointly with R.sub.2 ;
• and at least one of R.sub.4, R.sub.5, R.sub.6 and R.sub.7 represents --Y--(ONO.sub.2).sub.n and the remaining represent a hydrogen atom (Y represents straight or branched chain alkylene group having 1-6 carbon atoms or lower alkenylene group having 1-6 carbon atoms, and n represents an integer of 1-3.

A pharmaceutical composition comprising 0.01-99% chroman derivative represented by the following formula (1) and 1-99.99% of additives:

• ##STR9## wherein R.sub.1 represents cyano group, nitro group, halogenomethyl group or --SO.sub.2 --X group (X represents lower alkyl group having 1-6 carbon atoms or aryl group);
• R.sub.2 represents hydrogen atom or OA group (A represents hydrogen atom, nitro group, lower acyl group having 1-6 carbon atoms, arylcarbonyl group, lower alkylsulfonyl group having 1-6 carbon atoms, arylsulfonyl group, arylalky group, tetrahydropyranyl group, lower alkoxycarbonyl group having 1-6 carbon atoms, arylalkoxycarbonyl group or silyl derivative group):
• R.sub.3 singly represents a hydrogen atom;
• or R.sub.3 forms a bond jointly with R.sub.2 ;
• and at least one R.sub.4, R.sub.5, R.sub.6 and R.sub.7 represents --Y--(ONO.sub.2).sub.n and the remaining represent a hydrogen atom (Y represents straight or branched chain alkylene group having 1-6 carbon atoms or lower alkenylene group having 1-6 carbon atoms, and n represents an integer of 1-3.