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US 5,296,491 AGranted
Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsGregory M. Shutske, Kevin J. Kapples, John D. Tomer, IV
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Abstract
There are disclosed novel pyrazolo[4,3-c]pyridines of the formula ##STR1## where Ar and R.sub.1 are as defined in the specification, which are useful as serotonin reuptake inhibitors and as such may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
Claims80
A compound of the formula ##STR31## wherein Ar is ##STR32## or pyridyl;
- R.sub.1 is --(CH.sub.2).sub.p NR.sub.2 R.sub.3, ##STR33## R.sub.2 is hydrogen or loweralkyl;
- R.sub.3 is hydrogen or loweralkyl;
- R.sub.4 is hydrogen or loweralkyl;
- X and Y are independently hydrogen, halogen, trifluoromethyl, loweralkyl, loweralkoxy, nitro or hydroxy;
- n is 1, 2 or 3;
- m is 1 or 2;
- p and q are independently 2, 3 or 4;
- or a pharmaceutically acceptable addition salt and/or hydrate thereof, or where applicable, the optical or geometric isomer or racemic mixture thereof.
5 more elements
Dependencies are inferred from the claim text.