Back to results
US 5,296,482 AGranted
(Benzocycloalkyl) alkylamines
AssigneeAdir et Compagnie
InventorsJean-Louis Peglion, Joel Vian, Jean-Paul Vilaine, Nicole Villeneuve, Philip Janiak, Jean-Pierre Bidouard
Life of this patent
Estimating the term…
Abstract
The compounds are 3-[ (benzocycloalkyl)alkyl amino alkyl] -1,3,4,5-te trahydro 2H- 3-benzazepin-2 ones useful in cardiovascular field. A compound disclosed is (R,S)-7,8-dimethoxy-3-{3-{N-[(4,5-dimethoxybenzocyclobut-1-yl) methyl]-N-methyl amino}propyl}-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one.
Claims9
A compound selected from those of formula I ##STR7## in which m represents 2 to 5 inclusive,
- n represents 1 to 6 inclusive,
- p and q, which are the same or different, each represents 0, 1 or 2,
- with the proviso that the sum of p and 2 is equal to 1 or 2,
- R.sub.1 and R.sub.2, which are the same or different, each is selected from:
- hydrogen,
- halogen,
- hydroxy,
- lower alkoxy,
- phenyl-lower alkoxy,
- and substituted phenyl-lower alkoxy,
- or R.sub.1 and R.sub.2, when they are carried by 2 adjacent carbon atoms, together form --O--(CH.sub.2).sub.r --O-- in which r represents 1 or 2,
- R.sub.3 is selected from:
- hydrogen,
- lower alkyl,
- lower alkenyl,
- cycloalkyl,
- cycloalkyl-lower alkyl,
- phenyl-lower alkyl,
- substituted phenyl-lower alkyl,
- --CO--R.sub.5 or --CO--O--R.sub.5
- R.sub.5 being selected from:
- hydrogen, lower alkyl, lower alkenyl, lower alkynyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, cyclo alkyl, and cycloalkyl-lower alkyl,
- and --CO--NR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are the same or different and each has the same meanings as R.sub.5 as defined above,
- or R.sub.6 and R.sub.7, with the nitrogen atom carrying them, together a saturated heterocyclic ring having 4 to 7 ring members, inclusive, all members except the nitrogen being carbon
- R.sub.4 represents hydrogen or lower alkyl;
- X, Y and Z, which are the same or different, are each selected from:
- hydrogen,
- halogen,
- hydroxy,
- lower alkoxy,
- and substituted phenyl-lower alkoxy,
- or X and Y, or Y and Z, when they are carried by 2 adjacent carbon atoms, together form --O--(CH.sub.2).sub.r --O-- (in which r is 1 or 2), --O--(CH.sub.2)2-- or --O--CH.dbd.CH--;
- the term "substituted" describing the groups "phenyl" phenyl-lower alkyl" and "phenyl-lower alkoxy" meaning that those groups may be substituted in the phenyl nucleus by one or more substituents selected from halogen, hydroxy, trifluoromethyl, lower alkyl, and lower alkoxy,
- the terms "lower alkyl" and "lower alkoxy" meaning saturated linear or branched groups containing 1 to 6 carbon atoms inclusive,
- the terms "lower alkenyl" and "lower alkynyl" meaning unsaturated linear or branched groups
- containing 2 to 6 carbon atoms inclusive,
- the term "cycloalkyl" meaning a saturated hydrocarbon ring containing 3 to 8 inclusive, carbon atom in the ring,
- its possible optical isomers, as well as its addition salts with a pharmaceutically-acceptable acid.
35 more elements
A compound of formula (IV):
- ##STR8## in which m represents 2 to 5 inclusive,
- n represents 1 to 6 inclusive,
- p and q, which are the same or different, each represents 0, 1 or 2,
- with the proviso that the sum of p and 2 is equal to 1 or 2,
- R.sub.1 and R.sub.2, which are the same or different, each is selected from:
- hydrogen,
- halogen,
- hydroxy,
- lower alkoxy,
- phenyl-lower alkoxy,
- and substituted phenyl-lower alkoxy,
- or R.sub.1 and R.sub.2, when they are carried by 2 adjacent carbon atoms, together form --O--(CH.sub.2).sub.r --O-- in which r represents 1 or 2,
- R.sub.3 is selected from:
- hydrogen,
- lower alkyl,
- lower alkenyl,
- cycloalkyl,
- cycloalkyl-lower alkyl,
- phenyl-lower alkyl,
- substituted phenyl-lower alkyl,
- --CO--R.sub.5 or --CO--O--R.sub.5
- R.sub.5 being selected from:
- hydrogen, lower alkyl, lower alkenyl, lower alkynyl, phenyl, substituted phenyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, cyclo alkyl, and cycloalkyl-lower alkyl,
- and --CO--NR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are the same or different and each has the same meanings as R.sub.5 as defined above,
- or R.sub.6 and R.sub.7, with the nitrogen atom carrying them, together form a saturated heterocyclic ring having 4 to 7 ring members, inclusive, R.sub.4 represents hydrogen or lower alkyl;
- all members except the nitrogen being carbon
- X, Y and Z, which are the same or different, are each selected from:
- hydrogen,
- halogen,
- hydroxy,
- lower alkoxy,
- and substituted phenyl-lower alkoxy,
- or X and Y, or Y and Z, when they are carried by 2 adjacent carbon atoms, together form:
- --O--(CH.sub.2).sub.r --O-- (in which r is 1 or 2), --O--(CH.sub.2)2-- or --O--CH.dbd.CH--;
- the term "substituted" describing the groups "phenyl" phenyl-lower alkyl" and "phenyl-lower alkoxy" meaning that those groups may be substituted in the phenyl nucleus by one or more substituents selected from halogen, hydroxy, trifluoromethyl, lower alkyl, and lower alkoxy,
- the terms "lower alkyl" and "lower alkoxy" meaning saturated linear or branched groups containing 1 to 6 carbon atoms inclusive,
- the terms "lower alkenyl" and "lower alkynyl" meaning unsaturated linear or branched groups containing 2 to 6 carbon atoms inclusive,
- the term "cycloalkyl" meaning a saturated hydrocarbon ring containing 3 to 8 inclusive, carbon atom in the ring,
- its possible optical isomers, isolated or in the form of a mixture, and its addition salts with an acid.
36 more elements
Dependencies are inferred from the claim text.