Treatment process for promoting weight loss employing a substituted .DELTA. 5
AssigneeHumanetics Corporation
InventorsBruce E. Partridge, Henry A. Lardy
Life of this patent
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Abstract
A method for controlling weight gain or promoting weight loss which includes the step of treating a subject with an effective weight gain controlling or weight loss promoting amount of a substituted .DELTA.5-Androstene which is biologically effective for controlling weight gain or promoting weight loss and biologically ineffective for promoting the synthesis of sex hormones. Steroids believed to provide the desired weight control/weight loss characteristics include: .DELTA.5-Androstene-3.beta.,7.alpha.-diol-17-one .DELTA.5-Androstene-3.beta.-ol-7,17-dione .DELTA.5-Androstene-3.beta.,7.alpha.,17-triol .DELTA.5-Androstene-3.beta.,17.beta.-diol-7-one and various derivatives thereof.
Claims17
A method of preventatively treating weight gain which comprises administering to a subject in need of such treatment an effective amount of a steroid selected from the group consisting
- .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol,
- and
- .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one,
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
A method of treating excessive body fat which comprises administering to an overweight subject an effective amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol,
- and
- .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one,
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
A method of treating obesity which comprises administering to an obese subject a therapeutic amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol,
- and
- .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one,
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
A biologically active steroid effective for inhibiting weight gain without inducing a suppression of the appetite or promoting the synthesis of sex hormones comprising .DELTA.5-Androstene 3.beta.,7.alpha.,17.beta.-triol and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
A biologically active steroid effective for inhibiting weight gain without inducing a suppression of the appetite or promoting the synthesis of sex hormones comprising .DELTA.5-Androstene 3.beta.,17.beta.-diol-7-one, and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
A method of preventatively treating weight gain which comprises administering to a subject in need of such treatment an effective amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.-ol-7,17-dione
- and
- .DELTA.5-Androstene 3.beta.,7-diol-17-one
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
A method of treating excessive body fat which comprises administering to an overweight subject an effective amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.-ol-7,17-dione
- and
- .DELTA.5-Androstene 3.beta.,7-diol-17-one
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
A method of treating obesity which comprises administering to an obese subject a therapeutic amount of a steroid selected from the group consisting of
- .DELTA.5-Androstene 3.beta.-ol-7,17-dione
- and
- .DELTA.5-Androstene 3.beta.,7-diol-17-one
- and derivatives thereof wherein at least one of the hydroxyl groups is esterified with an acid selected from the group consisting of (i) a C.sub.2 to C.sub.22 aliphatic acid, (ii) a C.sub.7-12 aromatic acid (iii) a C.sub.3 or greater dicarboxylic acid in which only one of the carboxyl groups is esterified to the hydroxyl group(s) on the steroid;
- and (iv) an inorganic acid.
Dependencies are inferred from the claim text.