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US 5,296,480 AGranted
Angiotensin II receptor blocking 2,3,6-substituted 5,6,7,8-tetra-hydro-pyrido[4,3]pyrimidin-4(3H)-ones
AssigneeAmerican Cyanamid Company
InventorHoward Newman
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Abstract
The invention provides compounds having the formula ##STR1## wherein R, X and R.sup.6 are defined in the specification which have activity as angiotensin II antagonists.
Claims12
A pyrimidinone compound having the formula:
- ##STR8## wherein:
- R is ##STR9## X is a straight or branched alkyl of 3 to 5 carbon atoms;
- R.sup.6 is ##STR10## or pharmaceutically acceptable salts of these compounds.
A pyrimidinone compound having the formula:
- ##STR12## wherein X is a straight or branched alkyl of 3 to 5 carbon atoms;
- R.sup.6 is ##STR13##
A pyrimidinone compound having the formula:
- ##STR15## wherein:
- X is a straight or branched alkyl of 3 to 5 carbon atoms.
Dependencies are inferred from the claim text.