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US 5,296,478 AGranted
1-substituted oxindoles as cognition enhancers
AssigneeThe DuPont Merck Pharmaceutical Company
InventorChristopher A. Teleha
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Abstract
Compounds of Formula I have been shown to enhance the release of the neurotransmitter acetlcholine, and thus may be useful as chemical intermediates and as pharmacological agents in the treatment of diseases of man, such as in Alzheimer's Disease and other conditions involving learning and cognition, where subnormal levels of this neurochemical are found. ##STR1##
Claims8
A compound of formula:
- ##STR58## and pharmaceutically acceptable salts thereof, wherein:
- Q.sup.1, Q.sup.2 are each independently selected from the group:
- (a) 4, 3, or 2-pyridyl,
- (b) 2, 4, or 5-pyrimidyl,
- (c) 2-pyrazinyl,
- (d) 2-fluoro-4-pyridyl,
- (f) 3- or 4-pyridazinyl,
- (g) 2- or 3-tetrahydrofuranyl,
- A is CH;
- T is selected from the group:
- ##STR59## m and n are independently 0-1;
- and s is 0-3.
9 more elements
Dependencies are inferred from the claim text.