Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein

A method of reducing nitric oxide levels induced in an animal by a cytokine or by endotoxin, the method comprising administering to said animal an iron hemoprotein in an amount effective to bind or oxidize nitric oxide.

A method for treatment of systemic hypotension in a patient induced by chemotherapeutic treatment with a cytokine, the method comprising administering a therapeutically effective amount of an iron hemoprotein to said patient.

A method for treatment of systemic hypotension in a septic patient caused by endotoxin-induced nitric oxide production comprising intravascularly administering an amount of an iron hemoprotein sufficient to bind or oxidize substantially all of the nitric oxide produced.

A method for treatment of an animal for systemic hypotension caused by nitric oxide comprising administering a therapeutically effective amount of hemoglobin.

A method for thee treatment of an animal for systemic hypotension caused by endotoxin-induced nitric oxide production comprising administering a therapeutically effective amount of hemoglobin.

A method for treatment of systemic hypotension in a patient caused by nitric oxide production induced by a cytokine selected from the group consisting of tumor necrosis factor, interleukin-1, and interleukin-2 comprising administering an amount of hemoglobin sufficient to bind or oxidize substantially all of the nitric oxide produced.