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US 5,296,463 AGranted
Compositions and methods for improving cold tolerance in animals and humans
AssigneeUniversity of Alberta
InventorsTze-Fun Lee, Lawrence C. H. Wang
Life of this patent
Estimating the term…
Abstract
The invention disclosed is a composition for improving cold tolerance in animals and humans, comprising an adenosine receptor antagonist or an adenosine de-activator. Preferably, a nutritional supplement is also provided which further enhances cold tolerance. The nutritional supplement includes various combinations and amounts of carbohydrate, protein and fat.
Claims11
An orally ingestible composition for improving the cold tolerance of animals and humans which consists essentially of:
- (a) an adenosine receptor antagonist in an amount effective to improve the cold tolerance of said animals, said antagonist selected from the group of caffeine, theobromine, 8-phenyltheophylline, 8-cyclopentyltheophylline, 8-(4-(2-aminoethyl)amino carboxymethyloxyphenyl)-1,3-dipropylxanthine 8-(amino-4-chlorophenyl)-1,3-dipropylxanthine 8-(p-sulfophenyl)-1,3-dipropylxanthine, alone or mixed with two or more thereof, or in combination with theophylline or aminophylline or both;
- and
- (b) a nutritionally effective and cold tolerance improving amount of a nutritional supplement consisting of a mixture of 47 to 66% by weight of carbohydrate, 15 to 50% by weight of protein and 0 to 25% by weight of fat.
Dependencies are inferred from the claim text.