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US 5,296,379 AGranted
Apparatus and method for modeling arterial thrombus formations
OwnerPeter Gorog, Iren Kovacsinventors
Life of this patent
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Abstract
Apparatus and method for modeling of thrombogenesis using haemostasis measuring devices. A sleeve member is provided on a blood-carrying tube to simulate an environment of a human artery. When punctured with a small needle, bleeding is simulated, permitting blood to be trapped between the sleeve and blood-carrying tube. The trapped blood communicates with the blood flowing in the tube, resulting in thrombus formation.
Claims8
A method of modeling occlusive thrombosis formations in vitro comprising:
- supplying blood from a pressurized blood reservoir to a tubing which passes through a punching station to a collection reservoir;
- providing a sleeve over said tubing in a portion of the tubing which passes through said punching station;
- punching a needle hole in said sleeve and tubing at said punching station to stimulate bleeding, whereby blood exits said tubing and a portion of said blood is trapped between said tubing and said sleeve, some of the trapped blood contacting blood in said tubing thus forming a thrombus in said tubing which increases in size with time, and subsequently moves past said punching station;
- and,
- measuring a change in pressure in said tube to identify the formation of the thrombus.
2 more elements
An apparatus for modeling occlusion thrombosis in vitro comprising:
- a reservoir of blood including an outlet, and a source of pressuring media for forcing blood through said outlet;
- an elongate tube connected at one end to said outlet, having a portion which passes through a punching station and connected at an opposite end to a waste receptable;
- a sleeve member disposed over the portion of said elongate tube which passes through a punching station positioned to be pierced by a needle of said punching station, whereby blood exits the tube and is trapped between an exterior wall of said elongate tube and an interior wall of said sleeve, said trapped blood contacting blood flowing through said elongate tube, thus inducing the formation of a thrombus in blood flowing in said elongate tube;
- and,
- a pressure gauge connected to said elongate tube to monitor the fluid pressure in said elongate tube downstream from said punching station.
2 more elements
Dependencies are inferred from the claim text.