Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412
AssigneeMinistero Dell'Universita' e Della Ricerca Scientifica e Tecnologica
InventorsEzio A. Battistel, Pietro Cesti, Giuliana Franzosi, Vilhelmus van der Goes, Silvana Bonicelli, Mirella Pilone
Life of this patent
Estimating the term…
Abstract
The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R.sub.1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1 to 4 carbon atoms, is carried out by the oxidative deamination of compounds, or their salts, having the formula: ##STR2## with an oxidase D-Aminoacid enzyme derived from Rhodotorula glutinis NCIMB 40412. The enzyme can be in a free or immobilized form.
Claims13
A process for the enzymatic preparation of a cephalosporanic derivative, or a salt thereof, having the formula (I) ##STR5## wherein R is a --CO--COOH or --COOH group, and R' is H, OH, or --OCO--R", and R" is an alkyl group with from 1 to 4 carbon atoms, said process comprising oxidatively deaminating a compound, or a salt thereof, having the formula (II) ##STR6## in the presence of the D-amino acid oxidase enzyme extracted from the microorganism Phodotorula glutinis NCIMB 40412 or a mutant thereof capable of producing said enzyme.
Dependencies are inferred from the claim text.