Water-soluble pharmaceutical metallocene-complex composition
Assigneemedac Gesellschaft fur klinische Spzeialpraparate mbH
InventorsBernd W. Muller, Rainer Muller, Stefan Lucks, Wilfried Mohr
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Abstract
A water-soluble metallocene-complex composition which can be used as a cytostatic is described, which can be obtained by mixing a metallocene complex, a polyol, water and optionally additives, whereby glycols, sugar alcohols and carbohydrates are primarily used as the polyols.
Claims10
A water-soluble lyophilized powdered pharmaceutical composition consisting essentially of a metallocene complex of the formula (Cp).sub.2 M.sup.n X.sub.n-2 where Cp represents the cyclopentadienyl anion, M a transition metal of valency n, and X a mono- or polyvalent anion and a polyol selected from the group consisting of glycerol, 1,2-propylene glycol, 1,5-pentanediol, polyethylene glycol, a block copolymer of propylene glycol and ethylene glycol, pentaerythritol, sorbitol, mannitol, glucose, fructose, sucrose, lactose and mixtures thereof, which when re-solubilized in water forms a solution.
A water soluble, lyophilized powdered pharmaceutical composition prepared from an aqueous solution of 0.01 to 2% by weight of a metallocene complex of the formula (Cp).sub.2 M.sup.n X.sub.n-2 where Cp represents the cyclopentadienyl anion, M is a transition metal of valency n, and X a mono- or polyvalent anion, 58 to 99.89% by weight water, 0.1 to 20% by weight of a polyol selected from the group consisting of glycerol, 1,2-propylene glycol, 1,5-pentanediol, polyethylene glycol, a block copolymer of propylene glycol and ethylene glycol, pentaerythritol, sorbitol, mannitol, glucose, fructose, sucrose, lactose and mixtures thereof, from which solution the water has been removed.
Dependencies are inferred from the claim text.