Kava-kava extract, process for the production thereof and use thereof
AssigneeDr. Wilmar Schwabe GmbH & Co.
InventorKlaus-Peter Schwabe
Life of this patent
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Abstract
Dry extract from kava-kava drug having a total content of kava lactones of at least 50% by weight and a flavokawin content of at the most 0.3% by weight. The extract is distinguished by good water solubility and high bioavailability after oral administration. To increase the kava lactone content in the extract and decrease the flavokawin content, a process is proposed in which the raw extract is brought into solution and the content of flavokawins diminished by cold precipitation or by solvent distribution, whereafter the solution is concentrated to dryness. Drugs are made using the dry extract.
Claims13
Dry extract from the rhizome of Piper methysticum Forst., wherein said extract comprises a total content of kava lactones of at least 50% by weight and a flavokawin content of at most 0.3% by weight.
A process for the preparation of a dry extract from the rhizome of Piper methysticum Forst., comprising a total content of kava lactones of at least 50% by weight and a flavokawin content of at most 0.3% by weight, comprising the steps of:
- (a) extracting the pulverized rhizome of Piper methysticum Forst. (rhizoma kava-kava) with a first solvent to obtain an extract solution;
- (b) concentrating said extract solution to dryness to obtain a raw extract;
- (c) dissolving said raw extract in a second solvent to obtain a raw extract solution;
- (d) depleting the content of flavokawins in said raw extract solution by either cold precipitation or solvent distribution to obtain a pure extract solution;
- and
- (e) concentrating said pure extract solution to dryness to obtain said dry extract having a total content of kava lactones of at least 50% by weight and a flavokawin content of at most 0.3% by weight.
Dependencies are inferred from the claim text.