Subtilisin as an oral thrombolytic agent
AssigneeJCR Pharmaceuticals Co., Ltd.
InventorsKoichiro Nakanishi, Hajime Hiratani, Kazuo Kato
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Abstract
There are provided thrombolytic agents suited for oral administration. The agent comprises a proteolytic enzyme of subtilisin family, such as subtilisin BPN', subtilisin Carsberg, subtilisin amylosacchariticus, etc., produced by microorganisms belonging to genus Bacillus, such as Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens, etc. and, even when administered orally, exhibits thrombolytic activity.
Claims6
A method for treating thrombosis in a patient in need thereof comprising administering orally to said patient a therapeutically effective amount of a proteolytic subtilisin enzyme isolated from a microorganism of the genus Bacillus.
Dependencies are inferred from the claim text.