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US 5,296,222 AGranted
Percutaneous drug delivery system
AssigneeUniversity of Utah
InventorsRobert V. Petersen, Tsung-Min Hsu, Han-Chen Lee, Don Christy
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AssigneeUniversity of Utah
InventorsRobert V. Petersen, Tsung-Min Hsu, Han-Chen Lee, Don Christy
Estimating the term…
A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-2-one), and propylene glycol to a localized area of skin for a predetermined amount of time to enhance that area of skin's permeability to selected drug(s); occluding the area of skin during the application; and then applying the selected drug(s) to the area of skin to allow the drug to penetrate through the skin and into the circulatory system of the animal. Greatly enhanced penetration of chemicals through the skin results from the described treatment.
A percutaneous permeation enhancer comprising an enzyme component including a proteolytic enzyme selected to enhance the penetration of a chemical agent through skin in admixture with a potentiating amount of a non-enzymatic compound for enhancing the penetration of said chemical agent through said skin.
Dependencies are inferred from the claim text.