High resolution track etch autoradiography
AssigneesNew England Medical Center Hospitals, Inc., Massachusetts Institute of Technology
InventorsGuido Solares, Robert G. Zamenhof
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Abstract
A detector assembly for use in obtaining alpha-track autoradiographs, the detector assembly including a substantially boron-free substrate; a detector layer deposited on the substantially boron-free substrate, the detector layer being capable of recording alpha particle tracks and exhibiting evidence of the alpha tracks in response to being exposed to an etchant, the detector layer being less than about 2 microns thick; and a protective layer deposited on the detector layer, the protective layer being resistant to the etchant and having a thickness of about 0.5 to 1 microns.
Claims9
A method of etching a detector assembly with an etchant to produce high resolution autoradiographs, said detector assembly including a substrate on which is mounted a tissue sample, a protective layer that is resistant to said etchant and a detector layer for detecting radiation tracks in that order, the method comprising:
- placing a container for the etchant in a temperature stabilization bath, said container having an opening for adding the etchant;
- adding etchant to the container so as to cause a meniscus to form at the opening, said meniscus extending above the opening of the container;
- placing the detector assembly on top of the container so that said detector layer faces down and is in contact with the meniscus of etchant;
- and
- leaving the detector layer in contact with the etchant for sufficient time to etch radiation tracks in said detector layer.
Dependencies are inferred from the claim text.